CASE: Real Cases, Two Faculty Signatures
Dexter Hadley, MD/PhD (Penn) · CANONIC Foundation
title: CASE: Real Cases, Two Faculty Signatures date: 2026-05-12 author: Dexter Hadley, MD/PhD (Penn) · CANONIC Foundation tags: [nex, abopm, casenex, clinical-cases, genetic-counseling, msmc] scope: BLOGS _generated: true generator: gen-nex-fleet-doc (do_not_edit) — _generated by gen-nex-fleet-doc
Peer-reviewed clinical cases as the new way clinicians teach. At two in the morning, in a call room in Miami Beach, a fellow in clinical genetics is reading. The case in front of her is not a textbook case. It is a 62-year-old man with new-onset jaundice and a variant of uncertain significance in BRCA2. The fellow works the case to the diagnosis, sees what the reviewing faculty would have done, and flags the step that confused her so the next reader will see the clarification. The surface story is that peer review lives inside journals. The structural story is that peer review actually happens in call rooms, at morning report, in chart sign-out — and until now it left no citable trail.
What the App Is
The case came from CASE, a clinical-case library where every case is reviewed and signed by two faculty before publication, and patient identity is stripped before a case ever enters the editor. The cases are written by practising clinicians, in the voice of practising clinicians, against the same board curriculum the readers are studying.
The anchor partnership is with the medical genetics service at Mount Sinai Medical Center in Miami Beach, where Irman Forghani, MD, FACMG, leads the clinical review. The cases first published through CASE will come out of that service in private beta this summer; the public library opens shortly after.
CASE is what happens when peer review moves out of the journal and into the place where clinicians actually teach each other — the curbside, the morning report, the chart sign-out. Every step preserved, every signature attached, every patient protected.
ANKI, CASE, ONCO, and OMICS are the four apps a candidate uses to prepare for board certification in precision medicine. The figure is rebuilt from the same source files that drive the apps themselves.
Who Built It
Clinicians write the cases. Faculty reviewers sign them off. Mount Sinai's medical genetics service is the founding partner, with Irman Forghani as the clinical anchor.
What Is Verified About the Content
Every published case carries the author, the two reviewers, an evidence trail (ACMG criteria, ClinVar IDs, professional society guidelines), an ancestry disclosure, and a verified removal of identifying information. The cases live as signed bundles; nothing can be edited after publication without a new version and a new signature.
Where It Fits in Board Certification
CASE contributes to the genetic-counseling track of the ABOPM Foundation curriculum. The track is described in the chapter on genetic counseling inside the ABOPM book.
What It Costs and How to Use It
Reading is free. Authoring is open to credentialed clinicians in private beta with Mount Sinai and will open to the wider community after the first cases are published. Cases are downloadable as PDFs alongside their signed bundles.
What Is Next
In private beta with Mount Sinai Medical Center's genetics service. Public authoring opens once the first peer-reviewed case is signed.
The Real Peer Review
The real peer review is the one a fellow watches in the call room while reading a case her attendings already signed. The unlock is that the corridor conversation finally has a permanent record, with signatures attached and patient identity removed.
The Wider Picture
ANKI, CASE, ONCO, and OMICS share one permanent record. A flashcard, a case, a tumor-board thread, and a variant interpretation all sit on the same trail of evidence a candidate, a reviewer, or a board member can audit. For the full architecture, see Chapter 16 — Four Apps for Board Preparation.
CASE is the corridor conversation that finally leaves a signed, citable, patient-protected trail.
Sources
| Claim | Source | Ref |
|---|---|---|
| Variants of uncertain significance in BRCA2 are interpreted against ACMG criteria and ClinVar evidence | ACMG variant-classification standards (Richards et al., Genetics in Medicine) | pubmed.ncbi.nlm.nih.gov |
| Mount Sinai Medical Center in Miami Beach hosts the founding clinical-genetics partnership for CASE | Mount Sinai Medical Center | www.msmc.com |
| Verified removal of identifying patient information follows the HIPAA Privacy Rule safe-harbor method | HHS HIPAA Privacy Rule guidance | www.hhs.gov |
| ACMG fellowship credentialing anchors the two-faculty review signatures on every published case | American College of Medical Genetics and Genomics | www.acmg.net |
| ABOPM Foundation curriculum genetic-counseling track governs the CASE clinical-case library scope | ABOPM book (CANONIC) | hadleylab.org |
| Peer review in medical journals — the convention CASE moves from the journal into the call room | Smith — Peer review: a flawed process at the heart of science (J Roy Soc Med) | pubmed.ncbi.nlm.nih.gov |
| Mount Sinai Medical Center's genetics service is the founding clinical partner for CASE in private beta | CASENEX governance (CANONIC) | hadleylab.org |
CASE | CASES | MSMC | BLOGS