4:02
5G
CANONIC Galaxy · case-001 view
Federation IDE · cross-axiomatic discovery through magic://
CASE-001 · EVIDENCE CHAIN · GALAXY VIEW BRCA1 c.5266dupC · Pathogenic · Tier-1A · 45F Caribbean + Sephardic case-001 BRCA1 c.5266dupC PATHOGENIC · TIER-1A PVS1 null variant PS3 functional LOF PM2_S absent gnomAD PP5 ClinVar conf. ClinVar VCV055638 4★ gnomAD v4.1 AFR Findlay SGE −1.68 ClinGen ENIGMA VCEP COSMIC tumor profile F1CDx HRD+ 48% CPIC PARP-i 1A @adrienne CLASSIFY @irman PEER-SIGN @anil CO-SIGN CLASSIFY + ANCHOR_CITED ×7 CASE_PEER_REVIEW _SIGNED ×2 CASE_PUBLISHED + COIN +5 case-089 case-104 case-152 CARIBBEAN COHORT OncoNex tumor-board-014 AnkiNex card #17 boosted CaribChat cohort 151 PROVIDERS ACMG/AMP RULES SIGNATURES LEDGER EVENTS DOWNSTREAM PROPAGATION · cascade · cohort · cards
LLAUDE0.1.0(2)
A
Anil · Attending
where is case-001 propagating?
L
LAUDE
Case-001 feeding into: OmicsNex (variant cls) · AnkiNex (cards 1–22 signed by @adrienne) · OncoNex (tumor-board-protocol-014) · CaribChat (Trinidad cohort thread 89). All hash-chained.
A
Anil · Attending
propose new axiom: every case-bundle MUST declare a cohort tag before merge
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LAUDE
Opened PR #412 against APPS/CASENEX/CANON.md § Constraints: case_bundle_cohort_required: MUST. Awaiting 2 credentialed signers. COIN mints to all signers on merge.
Sign as second reviewer…
A
Anil is the precision-medicine attending. Tumor board, 4 PM. case-001 is on the agenda.
He opens Galaxy, sees the case feeding AnkiNex + OncoNex + CaribChat. Asks LAUDE to propose a new axiom in CANON.md. LAUDE opens PR #412. Two signatures merge it. COIN mints to all signers.
SLIDE ?? / ??
Attending · Precision Med · 4:02pm · Tumor board

Anil sees the whole graph.
And opens an axiom.

01
Galaxy is the federation IDE
Every governed scope, every CANON.md, every case-bundle as a navigable node. Galaxy is infrastructure — like LAUDE — not workload.
02
case-001 propagates in five directions
One artifact feeds: OmicsNex classification · AnkiNex cards 1–22 · OncoNex tumor-board protocol-014 · CaribChat Trinidad thread 89 · LAUDE's next discovery prompt.
03
Governance via natural language
"propose new axiom: every case-bundle MUST declare a cohort tag." LAUDE opens PR #412 against the governed CANON.md. Two credentialed signatures merge it.
04
The ABOPM credential is the gate
Open-write base (anyone reads, anyone proposes). Credentialed-write apex (only ABOPM-credentialed signatures merge axioms or peer-sign case-bundles). COIN mints on merge.
CANONIC Nexus
magic://hadleylab/GALAXY · case-001 federation view
LEDGER · GALAXY_NODE_VIEWED · AXIOM_PROPOSED · CANON_PR_OPENED